The Regina Studios & Hotel is located a short walk from the beach on the Greek island of Karpathos. Guests will find many places of interest on the island, including the Cave of Poseidon, the Folklore Museum of Othos, Mesochori village, Olympos village, the ruins of Potideon, the islet of Saria, and the windmills of Sporia. The Athens International Airport offers daily connections to the Karpathos Airport. Guests of the Regina Studios & Hotel will find many attractions within walking distance, but may also rent a car, bicycle, or motorcycle for travel around the island. Taxi services and public transportation are also available.

Each of the guest rooms at the Regina Studios & Hotel offers a private en suite bath with shower facilities. Guests will also find cable televisions, safes, refrigerators, Internet connections, kitchenettes, radios, and hair dryers. Every room boasts a private balcony overlooking the sea and the island landscape.

Many guest comforts are available at the Regina Studios & Hotel, including an outdoor pool with a sun deck, bar, and café. The reception services offer laundry, wake up calls, and fax capabilities. The hotel also has Internet services, and a PC for guests' use. A common veranda offers views of the sea, and breakfast is served each morning.